Elena Rainero Lab

Journal articles​​

• Rainero E. Overcoming Nutrient Stress: Integrin αvβ3-Driven Metabolic Adaptation Supports Tumor Initiation.Cancer Res. 2024 May 15;84(10):1543-1545. doi: 10.1158/0008-5472.CAN-24-0453.PMID: 38745495

• Rainero E. Macropinocytosis at the crossroad between nutrient scavenging and metabolism in cancer. Curr Opin Cell Biol. 2024 Apr 15;88:102359. doi: 10.1016/j.ceb.2024.102359. Online ahead of print.PMID: 38626703

• Nazemi M, Yanes B, Martinez ML, Walker HJ, Pham K, Collins MO, Bard F, Rainero E. The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism. PLoS Biol. 2024 Jan 16;22(1):e3002406. doi: 10.1371/journal.pbio.3002406. eCollection 2024 Jan.PMID: 38227562

• Yanes, B.; Rainero, E. (2022) The Interplay between Cell-Extracellular Matrix Interaction and Mitochondria Dynamics in Cancer. Cancers, 14, 1433. https://doi.org/10.3390/cancers14061433

• Nazemi M & Rainero E (2020) Cross-talk between the tumor microenvironment, extracellular matrix, and cell metabolism in cancer. Frontiers in Oncology, 10. 

• Llanses Martinez M & Rainero E (2019) Membrane dynamics in cell migration. Essays In Biochemistry. View this article in WRRO  

• Rainero E (2018) Extracellular matrix internalization links nutrient signalling to invasive migration. International Journal of Experimental Pathology. View this article in WRRO  

• Dornier E, Rabas N, Mitchell L, Novo D, Dhayade S, Marco S, Mackay G, Sumpton D, Pallares M, Nixon C , Blyth K et al (2017) Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nature Communications, 8. View this article in WRRO  

• Gundry C, Marco S, Rainero E, Miller B, Dornier E, Mitchell L, Caswell P, Campbel; A, Hogeweg A, Sansom O , Morton J et al (2017) Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nature Communications, 8. View this article in WRRO  

• Rainero E (2016) Extracellular matrix endocytosis in controlling matrix turnover and beyond: emerging roles in cancer. Biochemical Society Transactions, 44(5), 1347-1354. View this article in WRRO  

• Rainero E & Norman JC (2015) Endosomal integrin signals for survival. Nature Cell Biology, 17(11), 1373-1375. View this article in WRRO  

• Rainero E, Howe JD, Caswell PT, Jamieson NB, Anderson K, Critchley DR, Machesky L & Norman JC (2015) Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration. Cell Reports, 10(3), 398-413. View this article in WRRO  

• Macpherson IR, Rainero E, Mitchell LE, van den Berghe PVE, Speirs C, Dozynkiewicz MA, Chaudhary S, Kalna G, Edwards J, Timpson P & Norman JC (2014) CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer. Journal of Cell Science, 127(18), 3893-3901.  

• Rainero E & Norman JC (2013) Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion. BioEssays, 35(6), 523-532.  

• Rizzolio S, Rabinowicz N, Rainero E, Lanzetti L, Serini G, Norman J, Neufeld G & Tamagnone L (2012) Neuropilin-1-Dependent Regulation of EGF-Receptor Signaling. Cancer Research, 72(22), 5801-5811.  

• Christoforides C, Rainero E, Brown KK, Norman JC & Toker A (2012) PKD Controls αvβ3 Integrin Recycling and Tumor Cell Invasive Migration through Its Substrate Rabaptin-5. Developmental Cell, 23(3), 560-572.  

• Rainero E, Caswell PT, Muller PAJ, Grindlay J, McCaffrey MW, Zhang Q, Wakelam MJO, Vousden KH, Graziani A & Norman JC (2012) Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration. The Journal of Cell Biology, 196(2), 277-295. View this article in WRRO  

• Filigheddu N, Sampietro S, Chianale F, Porporato PE, Gaggianesi M, Gregnanin I, Rainero E, Ferrara M, Perego B, Riboni F , Baldanzi G et al (2011) Diacylglycerol kinase α mediates 17-β-estradiol-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line through the G protein-coupled estrogen receptor GPR30. Cellular Signalling, 23(12), 1988-1996.  

• Baldanzi G, Pighini A, Bettio V, Rainero E, Traini S, Chianale F, Porporato PE, Filigheddu N, Mesturini R, Song S , Schweighoffer T et al (2011) SAP-Mediated Inhibition of Diacylglycerol Kinase α Regulates TCR-Induced Diacylglycerol Signaling. The Journal of Immunology, 187(11), 5941-5951.  

• Rainero E & Norman JC (2011) New Roles for Lysosomal Trafficking in Morphogen Gradient Sensing. Science Signaling, 4(171), pe24-pe24.  

• Graziani A, Gaggianesi M, Porporato PE, Rainero E, Cianflone C, Ontano P, Pighini A, Chianale F, Chiorino G & Baldanzi G (2010) 754 DGKa, by regulating atypical PKC, is a key transducer of SDF1a-induced invasive behaviour in breast cancer cells. European Journal of Cancer Supplements, 8(5), 190-191.  

• Chianale F, Rainero E, Cianflone C, Bettio V, Pighini A, Porporato PE, Filigheddu N, Serini G, Sinigaglia F, Baldanzi G & Graziani A (2010) Diacylglycerol kinase   mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. Proceedings of the National Academy of Sciences, 107(9), 4182-4187.  

• Rainero E, Chianale F, Porporato PE, Cianflone C, Bettio V, Filigheddu N, Serini G & Graziani A (2009) HGF induces cell migration, ruffling and Rac activation through a novel signalling pathway coupling diacylglycerol kinase alpha to PKCz/i and RhoGDI. FEBS JOURNAL, 276, 250-250.  

• Baldanzi G, Cutrupi S, Chianale F, Gnocchi V, Rainero E, Porporato P, Filigheddu N, van Blitterswijk WJ, Parolini O, Bussolino F , Sinigaglia F et al (2008) Diacylglycerol kinase-α phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility. Oncogene, 27(7), 942-956.  

• Porporato PE, Rainero E, Chianale F, Ranaldo G, Arlandis GT, Locatelli I, Baldanzi G, Filigheddu N, Traini S, Gaggianesi M & Graziani A (2008) DIACYLGLYCEROL KINASE ALPHA IS REQUIRED FOR PROLIFERATION AND INVASION INDUCED BY GROWTH FACTORS AND CHEMOKINES. ANTICANCER RESEARCH, 28(5C), 3302-3303.  

• Chianale F, Cutrupi S, Rainero E, Baldanzi G, Porporato PE, Traini S, Filigheddu N, Gnocchi VF, Santoro MM, Parolini O , van Blitterswijk WJ et al (2007) Diacylglycerol Kinase-α Mediates Hepatocyte Growth Factor-induced Epithelial Cell Scatter by Regulating Rac Activation and Membrane Ruffling. Molecular Biology of the Cell, 18(12), 4859-4871.  

• Rainero E, Cianflone C, Porporato PE, Chianale F, Malacarne V, Bettio V, Ruffo E, Ferrara M, Benecchia F, Capello D , Paster W et al () The Diacylglycerol Kinase α/Atypical PKC/β1 Integrin Pathway in SDF-1α Mammary Carcinoma Invasiveness. PLoS ONE, 9(6), e97144-e97144. View this article in WRRO 

 

Pre-prints

• Montserrat Llanses Martinez, Keqian Nan, Zhe Bao, Rachele Bacchetti, Shengnan Yuan, Joe Tyler, Xavier Le Guezennec, Frédéric A. Bard,  Elena Rainero. Internalisation of integrin-bound extracellular matrix modulates invasive carcinoma cell migration. BioRxiv (2024). doi: https://doi.org/10.1101/2024.01.11.575153

• Shengnan Yuan, Rachele Bacchetti, Jamie Adams,  Elena Rainero. The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25. BioRxiv (2024). doi: https://doi.org/10.1101/2024.07.08.602517

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PhD theses 

• Llanses Martínez, Montserrat  (2023) Dissecting Extracellular Matrix Internalisation Mechanisms using Functional Genomics. PhD thesis, University of Sheffield. White Rose eTheses Online

• Nan, Keqian (2022) The role of ECM internalization in breast cancer cell migration and invasion. PhD thesis, University of Sheffield. White Rose eTheses Online

• Nazemi, Mona  (2021) ECM internalisation as a novel modulator of cancer cell growth/survival. PhD thesis, University of Sheffield. White Rose eTheses Online

 

Chapters

• Rainero E, van den Berghe PVE & Norman JC (2013) Internalisation, Endosomal Trafficking and Recycling of Integrins During Cell Migration and Cancer Invasion, Vesicle Trafficking in Cancer (pp. 327-359). Springer New York  

 

Conference proceedings papers

• Macpherson IR, Dornier E, Rabas N, Rainero E & Norman JC (2017) Abstract P6-01-06: Glutamine metabolism drives breast ca14ncer invasion by providing a source of extracellular glutamate to activate the GRM3 metabotropic glutamate receptor. Cancer Research, Vol. 77(4 Supplement), 6 December 2016 - 10 December 2016. View this article in WRRO  

• Macpherson IR, Rainero E, van den Berghe PVE, Speirs C, Dozynkiewicz MA, Chaudhary S, Kalna G, Edwards J, Timpson P & Norman JC (2014) CLIC3 controls delivery of late endosomal MT1-MMP to the ventral plasma membrane and dictates invasion and metastasis in estrogen receptor-negative breast cancer. EUROPEAN JOURNAL OF CANCER, Vol. 50 (pp S112-S112)  

• Bettio V, Rainero E, Romano A, Bryant DM, Datta A, Mostov KE & Graziani A (2011) Diacilglycerol kinase alpha regulates central lumen formation through Annexin2 and Cdc42. FEBS JOURNAL, Vol. 278 (pp 141-141)  

• Chianale F, Rainero E, Cianflone C, Bettio V, Pighini A, Porporato P, Filigheddu N, Serini G, Sinigaglia F, Baldanzi G & Graziani A (2010) Diacylglycerol Kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. FEBS JOURNAL, Vol. 277 (pp 124-124)  

• Cianflone C, Rainero E, Porporato PE, Chianale F, Gaggianesi M, Locatelli I, Ranaldo G, Baldanzi G & Graziani A (2010) Diacylglycerol kinase alpha regulates SDF1 alpha-induced cell invasion by regulating atypical PKC and matrix metallo proteinases 9. FEBS JOURNAL, Vol. 277 (pp 124-124)